CRISPR Solutions
Transforming genomes, one precise edit at a time.
Why Use CRISPR Sequencing?
CRISPR (clustered regularly interspaced short palindromic repeats) screening makes use of the robust CRISPR-Cas genome editing system to identify genes or pathways involved with diverse phenotypes or biological process. CRISPR screening has been widely used in many fields, including drug discovery to identify targets that either confer sensitivity or resistance to a drug, determine susceptibility to a disease state, discovery of components involved with cellular signaling, and more.
Admera Health takes this technology a step further. We offer expertly customized CRISPR screening services, tailored to your unique research goals. Our experienced team can design and execute complex screens that go beyond standard offerings, providing insights that are often unattainable with off-the-shelf solutions.
Admera Health offers complete CRISPR solutions for bulk and single-cell studies. Our team provides support from extraction through data analysis, with customized support tailored to your project. Utilizing high-throughput sequencing and advanced bioinformatic tools and pipelines, our team provides highly customized CRISPR screening services to best suit your project’s experimental design. Admera Health provides high-quality analyses with quick turnaround times to deliver precise genetic modifications and accelerate discovery.
CRISPR Screening Applications
Functional Genomics
Precise perturbation of genes and regulatory elements, facilitating identification of relationships between genetic variations and complex phenotypes
Disease Mechanisms
Systematic interrogation of gene function across the genome, pinpointing specific genes that, when altered, contribute to or protect against disease phenotypes
Drug Discovery
High-throughput, genome-wide functional analysis to identify novel therapeutic targets, elucidate disease mechanisms, and predict patient-specific drug responses
CRISPR Screening In Action
Discover how researchers used Admera Health’s CRISPR solutions to gain a deeper understanding of mouse ovarian cancer progression with 1:1 technical support from our team of experienced scientists.
Investigate genetic drivers of mouse ovarian cancer in vivo
Identify potential therapeutic targets for ovarian cancer
Accelerate the translation of basic research findings into clinical applications
End-to-end CRISPR Solutions
Bulk RNA & Single-cell Screening
Bulk gRNA Screening
PCR-based amplicon-seq
Using lentiviral libraries such as GeKOv2.0, pLG1, mTKO, Brunello, and more
QC count table, MAGeCK pair comparison
Single-cell gRNA screening
Guide RNA analysis powered by 10x Genomics or Parse Biosciences
sgRNA count in each cell, visualize the statistical significance and magnitude of gene expression changes associated with each sgRNA
CRISPR Editing & Indel Validation:
PCR-based amplicon-seq, target primer design, validation, library preparation, & sequencing
Bioinformatics QC, mapping, indel calling
On/off target analysis
WGS, IDT rhAmpSeq, GUIDE-seq
CRISPR cleavage specificity analysis pipelines
Our Optimized Workflow
CRISPR Solution Highlights
Exceptional data quality: stringent quality control steps ensure consistency for high-quality data delivery
High-Throughput Capacity: Cutting-edge technology & custom coverage capabilities provide the necessary throughput to support data-driven projects
Project Customization:
Our expert scientists curate customized primers & pipelines
to best suit your project’s experimental design
Rapid Delivery: Industry-leading turnaround time gets the data in your hands within 5-10 business days
Get the Most out of Your CRISPR Project
Maximize your project’s potential with advanced data analysis solutions. Our team of expert bioinformaticians curate pipelines tailored to your project’s experimental design.
See our sample submission guideline for sample preparation, packing, and shipping instructions.
