From Insight To Impact: Why Proteomics is Essential in the Age of Multi-Omics
The blueprint of life is encoded in our genes (genomics), and its active messages are transcribed into RNA (transcriptomics). But the true workhorses of the cell, the molecules that perform virtually all cellular functions, build structures, and execute signaling pathways, are proteins. This is where proteomics comes in – the large-scale study of proteins, their structures, and their functions.
While genomics reveals what could happen, proteomics tells us what is happening, right now, in a living system. It offers a direct window into cellular activity, providing insights often missed by DNA or RNA analysis alone. This makes proteomics an indispensable tool for understanding disease mechanisms, discovering novel biomarkers, validating drug targets, and monitoring therapeutic responses.
Key Applications of Proteomics in Scientific Discovery
Proteomics adds a crucial functional layer, revealing the downstream effects of these changes at the protein level. This integrated approach leads to more robust results.
Biomarker Discovery (Multi-omics Integration): NGS identifies genomic variants (SNPs, CNVs), differentially expressed genes, and gene fusion products. Proteomics then confirms the corresponding protein overexpression or underexpression, validating these genomic and transcriptomic changes at the protein level for more robust biomarker identification. We help you move beyond potential biomarkers to validated, functional ones.
Disease Research & Pathogenesis (Understanding Molecular Mechanisms): NGS reveals the genetic basis of disease and alterations in gene expression patterns. Proteomics provides the functional readout. By understanding what genes are mutated or differentially expressed via NGS, we can investigate the direct impact on protein levels, modifications, and interactions, providing a deeper understanding of disease mechanisms.
Drug Target Identification & Validation: NGS pinpoints genes or pathways dysregulated in disease, making them potential drug targets. Proteomics validates these targets at the protein level, characterizing their activity and understanding how drugs interact with them. This ensures that potential drug targets identified through NGS are functionally relevant.
Immuno-oncology and Immune Repertoire Analysis: Admera's NGS services, including single-cell immune profiling (scBCR-seq/TCR-seq) and RNA-seq, characterize immune cell populations and their gene expression. Proteomics then profiles immune checkpoint proteins, measures cytokine levels, and identifies neoantigens at the protein level, providing a comprehensive understanding of the immune response in cancer. NGS guides the proteomic focus for a more targeted and efficient analysis.
The Admera Health Advantage: Streamlined, Insight-Driven Proteomics
Admera Health empowers researchers with efficient, high-quality proteomics workflows designed to accelerate discovery and enhance data integration.
Streamlined Execution: From sample prep to data delivery, our standardized protocols and experienced scientific team ensure consistent, reliable results with rapid turnaround times.
Multi-Omics Expertise: We specialize in integrating proteomics data with genomic, transcriptomic, and epigenomic layers—enabling a systems-level understanding of complex biological processes.
Scientific Collaboration: Our experts support your project at every stage, from experimental design to in-depth data interpretation, helping you extract meaningful insights from proteomic analyses.
The Future of Multi-Omics Research Is Protein-Informed
Proteins shape the dynamics of every biological system. As research moves toward more integrated, multi-dimensional analysis, proteomics is a critical component in understanding biological function with precision and depth.
Admera Health is committed to enabling discovery through robust, scalable proteomic services that seamlessly integrate into broader multi-omics research strategies. Whether your work involves functional annotation, systems modeling, or experimental validation, we help you go beyond the genome—to the molecules that make biology work.