Long-Read Sequencing
Discover complete genomic insights with high-fidelity, long-read sequencing powered by PacBio Revio
What is Long-Read Sequencing?
Long read sequencing is a powerful next-generation sequencing (NGS) approach that generates reads thousands to tens of thousands of bases in length, far longer than traditional short-read methods. This technology provides a more complete view of the genome, enabling accurate detection of complex variants, structural rearrangements, and repetitive regions that shorter reads often miss.
At Admera Health, our long read sequencing services deliver high-quality, contiguous data that empower researchers to uncover deeper biological insights and accelerate genomic discovery.
PacBio Revio platform delivers long-read accuracy at scale, offering up to 15× higher throughput than previous systems. With Q30+ base precision, long read lengths, and efficient variant calling, Revio enables large and complex projects without sacrificing data quality.
HiFi long-read sequencing provides the clarity needed to tackle applications that demand comprehensive genomic resolution, including structural variant detection, full-length isoform sequencing, haplotype phasing, complex or repetitive region analysis, de novo genome assembly. By combining high volume with exceptional fidelity, the Revio system gives researchers access to comprehensive insights.
Long-Read vs.
Short-Read Sequencing
Both long read and short read sequencing technologies have transformed genomics, but each offers distinct advantages depending on research goals. Short read sequencing provides high-throughput, cost-effective data ideal for applications like variant detection and RNA profiling. In contrast, long read sequencing produces highly accurate, contiguous reads that capture complex genomic regions, structural variants, and full-length transcripts. Together, these complementary methods enable a more complete and precise understanding of the genome.
Long-Read Services at Admera
Long-read RNA Sequencing
With PacBio Revio, full-length transcript sequencing becomes seamless. HiFi reads span entire isoforms end to end, eliminating the need for assembly and enabling confident detection of alternative splicing, fusion events, and novel transcripts. This level of clarity supports functional annotation, biomarker discovery, and both bulk and single-cell transcriptomics.
Whole Genome Sequencing
Revio delivers highly accurate long reads that resolve complex genomic regions and structural variants that short-read platforms often miss. HiFi WGS supports de novo assembly, haplotype phasing, variant calling, and comprehensive analysis across human, model organism, and microbial genomes.
Amplicon Sequencing (Amplicon-seq)
Targeted sequencing with Revio allows long-range amplicons to be captured in a single read, covering full genes or difficult regions with ease. This approach is ideal for applications such as CRISPR edit verification, microbial typing, oncology panels, HLA sequencing, and low-frequency variant detection.
Metagenomics
Revio’s long reads improve taxonomic resolution and strain-level identification in complex microbial communities. HiFi data enables accurate assembly, functional profiling, and detection of low-abundance organisms without the bias introduced by short-read assembly.
Save on Long-Reads with Revio
Access savings on long-read savings on RNA, DNA, and premade library sequencing when you run on the Revio.